World Health OrganisationStudy to determine the cost-effectiveness and budget impact of the use of Quadrivalent vs Trivalent Infleunza Vaccines in South Africa and Vietnam.  

The overall goals of this project are to utilise the existing individual-based simulation model technology developed by our team to; (a) determine the effectiveness of quadrivalent (QIV) seasonal influenza vaccination compared to trivalent (TIV) vaccination over a 10-20 year timescale; (b) determine the relative cost-effectiveness of these alternative vaccine strategies in a South African and Vietnamese setting; (c) determine which factors (e.g. cost, vaccination targeting coverage) create scenarios where QIVs will be more cost-effective compared to TIVs; and (d) determine what premium QIV could bear (if any) and still be cost-beneficial over TIV.


Project partners:

·       Dr. Cheryl Cohen. Co-Head of the Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases, South Africa.

·        Prof. Maarten Postma, Faculty of Medicine, University of Groningen, The Netherlands.

·        Prof. Ian Barr   WHO Collaborating Cenre for Reference and Research on Influenza (VIDRL) Melbourne, Australia.

We are currently looking for PhD students in this area.

Related Publications

Milne, G.J., Halder, N., M., Kelso, J., Barr. I.G., Moyes, J., Kahn, K., Twine, R., Cohen, C. (2016), Comparing trivalent and quadrivalent influenza vaccination effectiveness in three global settings.   Influenza and Other Respiratory Viruses 


Study Methodology Overview

Study Method